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Several prostate cancers dispalyed strong nuclear positivity while breast and urothelial cancer showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
GATA2 (HGNC Symbol)
Synonyms
NFE1B
Description
GATA binding protein 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]