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EGR3

GENERAL INFORMATION

Gene name

 EGR3

Gene description

 Early growth response 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at transcript level

Protein expression

 General cytoplasmic expression. Also expressed in the nuclei in some cell types.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA006206 , CAB009373
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 EGR3 (HGNC Symbol)

Synonyms

 PILOT

Description

 Early growth response 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22687659 - 22693302

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000179388 (version 83.38)

Entrez gene

 1960

UniProt

 Q06889 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q06889

Antibodypedia

 EGR3 antibodies

PROTEIN BROWSER
EGR3-001
EGR3-002
EGR3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGR3-001
ENSP00000318057
ENST00000317216
Q06889 [Direct mapping]
Early growth response protein 3
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007422 [peripheral nervous system development]
GO:0007517 [muscle organ development]
GO:0007623 [circadian rhythm]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045586 [regulation of gamma-delta T cell differentiation]
GO:0046872 [metal ion binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
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 387 aa
42.6 kDa 		No 0
EGR3-002
ENSP00000429370
ENST00000519492
E5RIM5 [Direct mapping]
Early growth response protein 3
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Predicted intracellular proteins
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GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
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 71 aa
7.7 kDa 		No 0
EGR3-003
ENSP00000430310
ENST00000522910
Q06889 [Direct mapping]
Early growth response protein 3
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0007623 [circadian rhythm]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0043066 [negative regulation of apoptotic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0046872 [metal ion binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
Show all
 349 aa
38.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.