Cell atlas - ZBTB18 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ZBTB18
Gene description	Zinc finger and BTB domain containing 18
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules & nucleoplasm. In addition localized to the cytokinetic bridge.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Microtubules (supported)
Additional location	In addition localized to the Cytokinetic bridge (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition
Mouse	Localized to the Microtubules in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044652
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules & nucleoplasm. In addition localized to the cytokinetic bridge.

Main location

Nucleoplasm (supported), Microtubules (supported)

Additional location

Cytokinetic bridge (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA044652	A-431	Nucleoplasm
		Microtubules
		Cytokinetic bridge	Intensity	Intensity
HPA044652	U-2 OS	Nucleoplasm
HPA044652	U-2 OS	Microtubules
HPA044652	U-251 MG	Nucleoplasm
HPA044652	U-251 MG	Microtubules

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

MOUSE CELLS

Main location

Microtubules

Mouse gene

ENSMUSG00000063659 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA044652	NIH 3T3	Microtubules

GENE INFORMATION
Gene name	ZBTB18 (HGNC Symbol)
Synonyms	C2H2-171, RP58, TAZ-1, ZNF238
Description	Zinc finger and BTB domain containing 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	1
Cytoband	q44
Chromosome location (bp)	244048939 - 244057476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179456 (version 83.38)
Entrez gene	10472
UniProt	Q99592 (UniProt - Evidence at protein level)
neXtProt	NX_Q99592
Antibodypedia	ZBTB18 antibodies

PROTEIN BROWSER

ZBTB18-001	ZBTB18-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB18-001 ENSP00000351539 ENST00000358704	Q99592 [Direct mapping] Zinc finger and BTB domain-containing protein 18 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0001701 [in utero embryonic development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007519 [skeletal muscle tissue development] GO:0015630 [microtubule cytoskeleton] GO:0021549 [cerebellum development] GO:0021766 [hippocampus development] GO:0021987 [cerebral cortex development] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048666 [neuron development] GO:0048872 [homeostasis of number of cells] GO:0051302 [regulation of cell division] Show all	531 aa 59.4 kDa	No	0
ZBTB18-201 ENSP00000481278 ENST00000622512	Q99592 [Direct mapping] Zinc finger and BTB domain-containing protein 18 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007519 [skeletal muscle tissue development] GO:0015630 [microtubule cytoskeleton] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	522 aa 58.4 kDa	No	0