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SLC17A8

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GENERAL INFORMATION

Gene name

 SLC17A8

Gene description

 Solute carrier family 17 (vesicular glutamate transporter), member 8

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SLC17A8 (HGNC Symbol)

Synonyms

 DFNA25, VGLUT3

Description

 Solute carrier family 17 (vesicular glutamate transporter), member 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 q23.1

Chromosome location (bp)

 100357079 - 100422059

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179520 (version 83.38)

Entrez gene

 246213

UniProt

 Q8NDX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NDX2

Antibodypedia

 SLC17A8 antibodies

PROTEIN BROWSER
SLC17A8-001
SLC17A8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC17A8-001
ENSP00000316909
ENST00000323346
Q8NDX2 [Direct mapping]
Vesicular glutamate transporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0003407 [neural retina development]
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005771 [multivesicular body]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006836 [neurotransmitter transport]
GO:0007420 [brain development]
GO:0007605 [sensory perception of sound]
GO:0015293 [symporter activity]
GO:0015813 [L-glutamate transport]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0055085 [transmembrane transport]
GO:0060076 [excitatory synapse]
GO:0089711 [L-glutamate transmembrane transport]
GO:0090102 [cochlea development]
GO:0097440 [apical dendrite]
GO:0097441 [basilar dendrite]
GO:0097451 [glial limiting end-foot]
GO:1990030 [pericellular basket]
Show all
 589 aa
65 kDa 		No >9
SLC17A8-002
ENSP00000376715
ENST00000392989
Q8NDX2 [Direct mapping]
Vesicular glutamate transporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006836 [neurotransmitter transport]
GO:0007605 [sensory perception of sound]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 539 aa
59.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.