Cell atlas - SLITRK4 - The Human Protein Atlas

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SLITRK4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	SLITRK4
Gene description	SLIT and NTRK-like family, member 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Cell line enhanced (T-47d, HeLa, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA000431
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, HeLa, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000431	A-431	Microtubules
	HPA000431	U-2 OS	Microtubules
	HPA000431	U-251 MG	Microtubules

GENE INFORMATION
Gene name	SLITRK4 (HGNC Symbol)
Synonyms	DKFZp547M2010
Description	SLIT and NTRK-like family, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q27.3
Chromosome location (bp)	143622790 - 143635777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179542 (version 83.38)
Entrez gene	139065
UniProt	Q8IW52 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IW52
Antibodypedia	SLITRK4 antibodies

PROTEIN BROWSER

SLITRK4-001	SLITRK4-002	SLITRK4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLITRK4-001 ENSP00000349400 ENST00000356928	Q8IW52 [Direct mapping] SLIT and NTRK-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0016021 [integral component of membrane] Show all	837 aa 94.3 kDa	Yes	1
SLITRK4-002 ENSP00000336627 ENST00000338017	Q8IW52 [Direct mapping] SLIT and NTRK-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0016021 [integral component of membrane] Show all	837 aa 94.3 kDa	Yes	1
SLITRK4-201 ENSP00000469205 ENST00000596188	Q8IW52 [Direct mapping] SLIT and NTRK-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0016021 [integral component of membrane] GO:0051965 [positive regulation of synapse assembly] Show all	837 aa 94.3 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.