Expression of GRM8 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutamate receptor, metabotropic 8

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051481

GENE INFORMATION
Gene name	GRM8 (HGNC Symbol)
Synonyms	GLUR8, GPRC1H, mGlu8, MGLUR8
Description	Glutamate receptor, metabotropic 8 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.33
Chromosome location (bp)	126438598 - 127253294
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000179603 (version 83.38)
Entrez gene	2918
UniProt	O00222 (UniProt - Evidence at transcript level)
neXtProt	NX_O00222
Antibodypedia	GRM8 antibodies

PROTEIN BROWSER

GRM8-001	GRM8-002	GRM8-006	GRM8-011	GRM8-012	GRM8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM8-001 ENSP00000344173 ENST00000339582	O00222 [Direct mapping] Metabotropic glutamate receptor 8 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	908 aa 101.7 kDa	No	7
GRM8-002 ENSP00000351142 ENST00000358373	O00222 [Direct mapping] Metabotropic glutamate receptor 8 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	908 aa 101.6 kDa	No	7
GRM8-006 ENSP00000418255 ENST00000465844	H7C4V5 [Direct mapping] Metabotropic glutamate receptor 8 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	91 aa 10.1 kDa	No	0
GRM8-011 ENSP00000398012 ENST00000412160	C9J7I1 [Direct mapping] Metabotropic glutamate receptor 8 Show all	Predicted intracellular proteins Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	20 aa 2.2 kDa	No	0
GRM8-012 ENSP00000415522 ENST00000457830	E7ETK3 [Direct mapping] Metabotropic glutamate receptor 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	294 aa 32.5 kDa	No	0
GRM8-201 ENSP00000409790 ENST00000444921	A0A0A0MT06 [Direct mapping] Metabotropic glutamate receptor 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	416 aa 46.8 kDa	No	7