Expression of LRRC3B in cancer - Summary

CANCER ATLAS

Gene description

Leucine rich repeat containing 3B

Protein class

Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015568

GENE INFORMATION
Gene name	LRRC3B (HGNC Symbol)
Synonyms	LRP15
Description	Leucine rich repeat containing 3B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Chromosome	3
Cytoband	p24.1
Chromosome location (bp)	26622806 - 26710776
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179796 (version 83.38)
Entrez gene	116135
UniProt	Q96PB8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PB8
Antibodypedia	LRRC3B antibodies

PROTEIN BROWSER

LRRC3B-001	LRRC3B-002	LRRC3B-003	LRRC3B-004	LRRC3B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC3B-001 ENSP00000379880 ENST00000396641	Q96PB8 [Direct mapping] Leucine-rich repeat-containing protein 3B A0A024R2R0 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 3B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	259 aa 29.3 kDa	Yes	1
LRRC3B-002 ENSP00000406370 ENST00000417744	Q96PB8 [Direct mapping] Leucine-rich repeat-containing protein 3B A0A024R2R0 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 3B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	259 aa 29.3 kDa	Yes	1
LRRC3B-003 ENSP00000394940 ENST00000456208	Q96PB8 [Direct mapping] Leucine-rich repeat-containing protein 3B A0A024R2R0 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 3B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	259 aa 29.3 kDa	Yes	1
LRRC3B-004 ENSP00000389764 ENST00000414619	C9JMC7 [Direct mapping] Leucine-rich repeat-containing protein 3B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		55 aa 5.9 kDa	Yes	0
LRRC3B-005 ENSP00000398184 ENST00000432040	C9J6A1 [Direct mapping] Leucine-rich repeat-containing protein 3B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	163 aa 18.3 kDa	Yes	0