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B3GNT3

GENERAL INFORMATION

Gene name

 B3GNT3

Gene description

 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum)
GTEx:Tissue enhanced (stomach, salivary gland)
FANTOM5:Tissue enhanced (small intestine, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastrointestinal tract, placenta and urinary bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA024298
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, gallbladder)

GENE INFORMATION

Gene name

 B3GNT3 (HGNC Symbol)

Synonyms

 B3GN-T3, B3GNT-3, beta3Gn-T3, HP10328, TMEM3

Description

 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 17794828 - 17813082

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179913 (version 83.38)

Entrez gene

 10331

UniProt

 Q9Y2A9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2A9

Antibodypedia

 B3GNT3 antibodies

PROTEIN BROWSER
B3GNT3-001
B3GNT3-003
B3GNT3-005
B3GNT3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
B3GNT3-001
ENSP00000321874
ENST00000318683
Q9Y2A9 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0008532 [N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016266 [O-glycan processing]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030311 [poly-N-acetyllactosamine biosynthetic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047223 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity]
Show all
 372 aa
42.5 kDa 		Yes 0
B3GNT3-003
ENSP00000472638
ENST00000595387
Q9Y2A9 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0008532 [N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016266 [O-glycan processing]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030311 [poly-N-acetyllactosamine biosynthetic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047223 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity]
Show all
 372 aa
42.5 kDa 		Yes 0
B3GNT3-005
ENSP00000471733
ENST00000599265
M0R199 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006486 [protein glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 250 aa
28.7 kDa 		Yes 0
B3GNT3-006
ENSP00000468914
ENST00000600777
M0QX58 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006486 [protein glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0016020 [membrane]
Show all
 127 aa
14.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.