Cell atlas - EXOC3 - The Human Protein Atlas

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EXOC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EXOC3
Gene description	Exocyst complex component 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037880
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037880	A-431	Nucleoplasm
	HPA037880	A-431	Mitochondria	Intensity
	HPA037880	U-2 OS	Nucleoplasm
	HPA037880	U-2 OS	Mitochondria	Intensity	Intensity
	HPA037880	U-251 MG	No staining

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA037880	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. EXOC3 is mostly expressed during G1.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Mitochondria

GENE INFORMATION
Gene name	EXOC3 (HGNC Symbol)
Synonyms	SEC6L1, Sec6p
Description	Exocyst complex component 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	443158 - 471937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180104 (version 83.38)
Entrez gene	11336
UniProt	O60645 (UniProt - Evidence at protein level)
neXtProt	NX_O60645
Antibodypedia	EXOC3 antibodies

PROTEIN BROWSER

EXOC3-001	EXOC3-004	EXOC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOC3-001 ENSP00000425587 ENST00000512944	O60645 [Direct mapping] Exocyst complex component 3 A0A024QYZ6 [Target identity:100%; Query identity:100%] Exocyst complex component 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0030667 [secretory granule membrane] GO:0044267 [cellular protein metabolic process] GO:0051601 [exocyst localization] GO:0061024 [membrane organization] Show all	745 aa 85.6 kDa	No	0
EXOC3-004 ENSP00000422596 ENST00000508022	D6RBR9 [Direct mapping] Exocyst complex component 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0006887 [exocytosis] GO:0051601 [exocyst localization] Show all	69 aa 7.8 kDa	No	0
EXOC3-201 ENSP00000323377 ENST00000315013	O60645 [Direct mapping] Exocyst complex component 3 A0A024QYZ6 [Target identity:100%; Query identity:100%] Exocyst complex component 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0000149 [SNARE binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0030667 [secretory granule membrane] GO:0044267 [cellular protein metabolic process] GO:0051601 [exocyst localization] GO:0061024 [membrane organization] Show all	745 aa 85.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.