Expression of LYNX1 in cancer - Summary

CANCER ATLAS

Gene description

Ly6/neurotoxin 1

Protein class

Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023711

GENE INFORMATION
Gene name	LYNX1 (HGNC Symbol)
Synonyms	SLURP2
Description	Ly6/neurotoxin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142764334 - 142778224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180155 (version 83.38)
Entrez gene	66004
UniProt	Q9BZG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZG9
Antibodypedia	LYNX1 antibodies

PROTEIN BROWSER

LYNX1-001	LYNX1-002	LYNX1-003	LYNX1-004	LYNX1-005	LYNX1-007	LYNX1-008	LYNX1-009	LYNX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYNX1-001 ENSP00000479586 ENST00000615007	Q9BZG9 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	131 aa 14 kDa	Yes	0
LYNX1-002 ENSP00000319846 ENST00000317543	Q9BZG9 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	97 aa 10.2 kDa	Yes	0
LYNX1-003 ENSP00000478390 ENST00000621401	Q9BZG9 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	116 aa 12.6 kDa	Yes	1
LYNX1-004 ENSP00000428465 ENST00000521396	H0YB12 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 8.9 kDa	Yes	0
LYNX1-005 ENSP00000481790 ENST00000613110	A0A087WYG6 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.4 kDa	Yes	0
LYNX1-007 ENSP00000478402 ENST00000620006	Q9BZG9 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	116 aa 12.6 kDa	Yes	1
LYNX1-008 ENSP00000482846 ENST00000614268	A0A087WZS0 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 9.2 kDa	Yes	0
LYNX1-009 ENSP00000428713 ENST00000523332	G3V0Z9 [Direct mapping] HCG2043033, isoform CRA_b; Ly-6/neurotoxin-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 9 kDa	Yes	0
LYNX1-201 ENSP00000477648 ENST00000614491	Q9BZG9 [Direct mapping] Ly-6/neurotoxin-like protein 1 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	116 aa 12.6 kDa	Yes	1