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PRKRA

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GENERAL INFORMATION

Gene name

 PRKRA

Gene description

 Protein kinase, interferon-inducible double stranded RNA dependent activator

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nucleoplasm (supported)

Mouse

 Localized to the Nucleus, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA034996 , HPA034997
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (supported)

Additional location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA034996 A-431 Nucleoplasm
Cytosol
HPA034996 PC-3 No staining    
HPA034996 U-2 OS Nucleoplasm
Cytosol
HPA034997 A-431 Cytosol
HPA034997 PC-3 Cytosol
HPA034997 U-2 OS Cytosol

MOUSE CELLS

Main location

 Nucleus, Cytosol

Mouse gene

 ENSMUSG00000002731 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA034996 NIH 3T3 Cytosol
HPA034997 NIH 3T3 Nucleus
Cytosol

GENE INFORMATION

Gene name

 PRKRA (HGNC Symbol)

Synonyms

 DYT16, HSD14, PACT, RAX

Description

 Protein kinase, interferon-inducible double stranded RNA dependent activator (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 178431414 - 178451512

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180228 (version 83.38)

Entrez gene

 8575

UniProt

 O75569 (UniProt - Evidence at protein level)

neXtProt

 NX_O75569

Antibodypedia

 PRKRA antibodies

PROTEIN BROWSER
PRKRA-001
PRKRA-003
PRKRA-008
PRKRA-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKRA-001
ENSP00000318176
ENST00000325748
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0034599 [cellular response to oxidative stress]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042473 [outer ear morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048705 [skeletal system morphogenesis]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 313 aa
34.4 kDa 		No 0
PRKRA-003
ENSP00000430604
ENST00000487082
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 288 aa
31.6 kDa 		No 0
PRKRA-008
ENSP00000408668
ENST00000457633
C9JMM3 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
12 kDa 		No 0
PRKRA-009
ENSP00000393883
ENST00000432031
O75569 [Direct mapping]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0008047 [enzyme activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 302 aa
33.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.