Expression of SLC9A4 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036096

GENE INFORMATION
Gene name	SLC9A4 (HGNC Symbol)
Synonyms	NHE4
Description	Solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102473303 - 102533972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180251 (version 83.38)
Entrez gene	389015
UniProt	Q6AI14 (UniProt - Evidence at protein level)
neXtProt	NX_Q6AI14
Antibodypedia	SLC9A4 antibodies

PROTEIN BROWSER

SLC9A4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A4-001 ENSP00000295269 ENST00000295269	Q6AI14 [Direct mapping] Sodium/hydrogen exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001696 [gastric acid secretion] GO:0002064 [epithelial cell development] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	798 aa 89.8 kDa	Yes	>9