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Colorectal cancers, several breast, ovarian, endometrial, testicular and stomach cancers along with a few cases of lymphomas, urothelial and pancreatic cancers displayed weak to moderate membranous and cytoplasmic positivity. Few cholangiocarcinomas showed strong membranous staining. Most remaining cancers were negative.
GENE INFORMATION
Gene name
FZD2
Synonyms
Description
Frizzled class receptor 2 (HGNC Symbol)
Entrez gene summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]