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A majority of malignant tissues showed weak to moderate cytoplasmic staining. Malignant lymphomas, ovarian and colorectal cancers displayed moderate to strong immunoreactivity.
GENE INFORMATION
Gene name
PAK2 (HGNC Symbol)
Synonyms
PAK65, PAKgamma
Description
P21 protein (Cdc42/Rac)-activated kinase 2 (HGNC Symbol)
Entrez gene summary
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Q13177 [Direct mapping] Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0018105 [peptidyl-serine phosphorylation] GO:0019901 [protein kinase binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030036 [actin cytoskeleton organization] GO:0030296 [protein tyrosine kinase activator activity] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0031295 [T cell costimulation] GO:0032147 [activation of protein kinase activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0040008 [regulation of growth] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043408 [regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048365 [Rac GTPase binding] GO:0048471 [perinuclear region of cytoplasm] GO:0050690 [regulation of defense response to virus by virus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050852 [T cell receptor signaling pathway] GO:0060996 [dendritic spine development] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0071407 [cellular response to organic cyclic compound] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] GO:2001271 [negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]