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CYP8B1

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GENERAL INFORMATION

Gene name

 CYP8B1

Gene description

 Cytochrome P450, family 8, subfamily B, polypeptide 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BEWO)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CYP8B1 (HGNC Symbol)

Synonyms

 CYP12

Description

 Cytochrome P450, family 8, subfamily B, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.1

Chromosome location (bp)

 42856005 - 42876165

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180432 (version 83.38)

Entrez gene

 1582

UniProt

 Q9UNU6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNU6

Antibodypedia

 CYP8B1 antibodies

PROTEIN BROWSER
CYP8B1-001
CYP8B1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP8B1-001
ENSP00000318867
ENST00000316161
Q9UNU6 [Direct mapping]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006699 [bile acid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008397 [sterol 12-alpha-hydroxylase activity]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0033778 [7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 501 aa
58.1 kDa 		No 1
CYP8B1-002
ENSP00000404499
ENST00000437102
C9JFR9 [Direct mapping]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 496 aa
57.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.