Cell atlas - GAS1 - The Human Protein Atlas

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GAS1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GAS1
Gene description	Growth arrest-specific 1
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Cell line enhanced (RH-30, BJ hTERT+, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036085
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, BJ hTERT+, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036085	HEK 293	Nuclear speckles
	HPA036085	HeLa	Nuclear speckles
	HPA036085	HeLa	Cytosol
	HPA036085	U-2 OS	Nuclear speckles

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000052957 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA036085	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	GAS1
Synonyms
Description	Growth arrest-specific 1 (HGNC Symbol)
Entrez gene summary	Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	86944363 - 86947189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180447 (version 83.38)
Entrez gene	2619
UniProt	P54826 (UniProt - Evidence at transcript level)
neXtProt	NX_P54826
Antibodypedia	GAS1 antibodies

PROTEIN BROWSER

GAS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAS1-001 ENSP00000298743 ENST00000298743	P54826 [Direct mapping] Growth arrest-specific protein 1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007050 [cell cycle arrest] GO:0008589 [regulation of smoothened signaling pathway] GO:0010955 [negative regulation of protein processing] GO:0016021 [integral component of membrane] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0042981 [regulation of apoptotic process] GO:0045165 [cell fate commitment] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046658 [anchored component of plasma membrane] GO:0048589 [developmental growth] GO:0060628 [regulation of ER to Golgi vesicle-mediated transport] Show all	345 aa 35.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.