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KCNE1

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GENERAL INFORMATION

Gene name

 KCNE1

Gene description

 Potassium channel, voltage gated subfamily E regulatory beta subunit 1

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (CACO-2, BJ hTERT+ SV40 Large T+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, BJ hTERT+ SV40 Large T+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KCNE1 (HGNC Symbol)

Synonyms

 ISK, JLNS2, LQT5, minK

Description

 Potassium channel, voltage gated subfamily E regulatory beta subunit 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.12

Chromosome location (bp)

 34446688 - 34512275

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180509 (version 83.38)

Entrez gene

 3753

UniProt

 P15382 (UniProt - Evidence at protein level)

neXtProt

 NX_P15382

Antibodypedia

 KCNE1 antibodies

PROTEIN BROWSER
KCNE1-001
KCNE1-002
KCNE1-003
KCNE1-005
KCNE1-201
KCNE1-202
KCNE1-203
KCNE1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNE1-001
ENSP00000382228
ENST00000399289
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-002
ENSP00000382226
ENST00000399286
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-003
ENSP00000416258
ENST00000416357
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-005
ENSP00000382225
ENST00000399284
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-201
ENSP00000337255
ENST00000337385
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-202
ENSP00000412498
ENST00000432085
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-203
ENSP00000478215
ENST00000611936
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1
KCNE1-204
ENSP00000483895
ENST00000621601
P15382 [Direct mapping]
Potassium voltage-gated channel subfamily E member 1
C7S316 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel Isk-related family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006487 [protein N-linked glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0006811 [ion transport]
GO:0007605 [sensory perception of sound]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030018 [Z disc]
GO:0031433 [telethonin binding]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization]
GO:0086009 [membrane repolarization]
GO:0086011 [membrane repolarization during action potential]
GO:0086013 [membrane repolarization during cardiac muscle cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090315 [negative regulation of protein targeting to membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1902282 [voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
Show all
 129 aa
14.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.