Tissue expression of CHRM4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CHRM4
Gene description	Cholinergic receptor, muscarinic 4
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen, cerebral cortex, small intestine)
GTEx:	Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB022444
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, cerebral cortex, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION
Gene name	CHRM4
Synonyms
Description	Cholinergic receptor, muscarinic 4 (HGNC Symbol)
Entrez gene summary	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	46385098 - 46386608
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180720 (version 83.38)
Entrez gene	1132
UniProt	P08173 (UniProt - Evidence at transcript level)
neXtProt	NX_P08173
Antibodypedia	CHRM4 antibodies

PROTEIN BROWSER

CHRM4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRM4-001 ENSP00000409378 ENST00000433765	P08173 [Direct mapping] Muscarinic acetylcholine receptor M4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007606 [sensory perception of chemical stimulus] GO:0008283 [cell proliferation] GO:0010033 [response to organic substance] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0032279 [asymmetric synapse] GO:0040012 [regulation of locomotion] GO:0042383 [sarcolemma] GO:0043025 [neuronal cell body] GO:0043547 [positive regulation of GTPase activity] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	479 aa 53 kDa	No	7