Expression of CXCR2 in cancer - Summary

CANCER ATLAS

Gene description

Chemokine (C-X-C motif) receptor 2

Protein class

Cancer-related genes, CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031999	HPA032017	CAB016268

GENE INFORMATION
Gene name	CXCR2 (HGNC Symbol)
Synonyms	CD182, CMKAR2, IL8RB
Description	Chemokine (C-X-C motif) receptor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218125289 - 218137253
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180871 (version 83.38)
Entrez gene	3579
UniProt	P25025 (UniProt - Evidence at protein level)
neXtProt	NX_P25025
Antibodypedia	CXCR2 antibodies

PROTEIN BROWSER

CXCR2-001	CXCR2-002	CXCR2-003	CXCR2-004	CXCR2-005	CXCR2-006	CXCR2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXCR2-001 ENSP00000319635 ENST00000318507	P25025 [Direct mapping] C-X-C chemokine receptor type 2 Q53PC4 [Target identity:100%; Query identity:100%] Interleukin 8 receptor, beta; Putative uncharacterized protein IL8RB; cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA; cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002407 [dendritic cell chemotaxis] GO:0002438 [acute inflammatory response to antigenic stimulus] GO:0002690 [positive regulation of leukocyte chemotaxis] GO:0004871 [signal transducer activity] GO:0004918 [interleukin-8 receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008284 [positive regulation of cell proliferation] GO:0009986 [cell surface] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019959 [interleukin-8 binding] GO:0030593 [neutrophil chemotaxis] GO:0030901 [midbrain development] GO:0031623 [receptor internalization] GO:0033030 [negative regulation of neutrophil apoptotic process] GO:0038112 [interleukin-8-mediated signaling pathway] GO:0042119 [neutrophil activation] GO:0042629 [mast cell granule] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0045766 [positive regulation of angiogenesis] GO:0070098 [chemokine-mediated signaling pathway] GO:0072173 [metanephric tubule morphogenesis] GO:0090023 [positive regulation of neutrophil chemotaxis] Show all	360 aa 40.8 kDa	No	7
CXCR2-002 ENSP00000413686 ENST00000453237	C9JW47 [Direct mapping] C-X-C chemokine receptor type 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019959 [interleukin-8 binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	201 aa 22.7 kDa	No	4
CXCR2-003 ENSP00000410506 ENST00000449014	Q6LCZ7 [Direct mapping] C-X-C chemokine receptor type 2; Interleukin-8 receptor type B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.9 kDa	No	0
CXCR2-004 ENSP00000415148 ENST00000454148	C9JG19 [Direct mapping] C-X-C chemokine receptor type 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019959 [interleukin-8 binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	136 aa 15.3 kDa	No	3
CXCR2-005 ENSP00000392698 ENST00000428565	C9J1J7 [Direct mapping] C-X-C chemokine receptor type 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019959 [interleukin-8 binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	172 aa 19.5 kDa	No	3
CXCR2-006 ENSP00000416815 ENST00000418878	Q6LCZ7 [Direct mapping] C-X-C chemokine receptor type 2; Interleukin-8 receptor type B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.9 kDa	No	0
CXCR2-007 ENSP00000392348 ENST00000415392	C9J2F9 [Direct mapping] C-X-C chemokine receptor type 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0019959 [interleukin-8 binding] GO:0070098 [chemokine-mediated signaling pathway] Show all	138 aa 15.5 kDa	No	3