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RPH3AL

CANCER ATLAS

Gene description

 Rabphilin 3A-like (without C2 domains)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA024311

GENE INFORMATION

Gene name

 RPH3AL (HGNC Symbol)

Synonyms

 Noc2

Description

 Rabphilin 3A-like (without C2 domains) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 212389 - 386254

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181031 (version 83.38)

Entrez gene

 9501

UniProt

 Q9UNE2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNE2

Antibodypedia

 RPH3AL antibodies

PROTEIN BROWSER
«
RPH3AL-001
RPH3AL-002
RPH3AL-003
RPH3AL-005
RPH3AL-006
RPH3AL-008
RPH3AL-009
RPH3AL-010
RPH3AL-011
RPH3AL-012
RPH3AL-013
RPH3AL-015
RPH3AL-016
RPH3AL-018
RPH3AL-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPH3AL-001
ENSP00000328977
ENST00000331302
Q9UNE2 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008092 [cytoskeletal protein binding]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030141 [secretory granule]
GO:0030274 [LIM domain binding]
GO:0030276 [clathrin binding]
GO:0030658 [transport vesicle membrane]
GO:0030667 [secretory granule membrane]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050714 [positive regulation of protein secretion]
Show all
 315 aa
34.5 kDa 		No 0
RPH3AL-002
ENSP00000319210
ENST00000323434
Q9UNE2 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008092 [cytoskeletal protein binding]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030658 [transport vesicle membrane]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 286 aa
31.2 kDa 		No 0
RPH3AL-003
ENSP00000438224
ENST00000536489
Q9UNE2 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008092 [cytoskeletal protein binding]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030658 [transport vesicle membrane]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 286 aa
31.2 kDa 		No 0
RPH3AL-005
ENSP00000460171
ENST00000575130
I3L349 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 110 aa
12.5 kDa 		No 0
RPH3AL-006
ENSP00000459992
ENST00000573780
I3L2X0 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 145 aa
16.5 kDa 		No 0
RPH3AL-008
ENSP00000459795
ENST00000577079
I3L2N0 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 193 aa
22.1 kDa 		No 0
RPH3AL-009
ENSP00000461885
ENST00000575634
I3NI49 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 88 aa
10.3 kDa 		No 0
RPH3AL-010
ENSP00000459001
ENST00000575736
I3L1Q0 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 126 aa
14.3 kDa 		No 0
RPH3AL-011
ENSP00000460580
ENST00000570638
I3L3M9 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 152 aa
17.3 kDa 		No 0
RPH3AL-012
ENSP00000460080
ENST00000576420
I3L308 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 201 aa
23.1 kDa 		No 0
RPH3AL-013
ENSP00000458643
ENST00000573448
I3L181 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 38 aa
4.3 kDa 		No 0
RPH3AL-015
ENSP00000459975
ENST00000573588
I3L2W0 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 83 aa
9.7 kDa 		No 0
RPH3AL-016
ENSP00000459716
ENST00000574722
I3L2I9 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 149 aa
17.1 kDa 		No 0
RPH3AL-018
ENSP00000459666
ENST00000574953
I3L2G8 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 157 aa
18.1 kDa 		No 0
RPH3AL-201
ENSP00000479485
ENST00000618002
Q9UNE2 [Direct mapping]
Rab effector Noc2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008092 [cytoskeletal protein binding]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017137 [Rab GTPase binding]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030658 [transport vesicle membrane]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 315 aa
34.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.