Cell atlas - SLC26A11 - The Human Protein Atlas

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SLC26A11

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm
	Vesicles

Human cell
	Golgi Apparatus
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	SLC26A11
Gene description	Solute carrier family 26 (anion exchanger), member 11
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus & vesicles. In addition localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029893
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus & vesicles. In addition localized to the nucleoplasm.

Main location

Golgi apparatus (approved), Vesicles (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029893	CACO-2	No staining
	HPA029893	MCF7	Nucleoplasm
			Golgi apparatus
			Vesicles
	HPA029893	U-2 OS	Golgi apparatus
	HPA029893	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SLC26A11
Synonyms
Description	Solute carrier family 26 (anion exchanger), member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	80219699 - 80253500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181045 (version 83.38)
Entrez gene	284129
UniProt	Q86WA9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86WA9
Antibodypedia	SLC26A11 antibodies

PROTEIN BROWSER

SLC26A11-001	SLC26A11-002	SLC26A11-003	SLC26A11-005	SLC26A11-006	SLC26A11-007	SLC26A11-009	SLC26A11-010	SLC26A11-013	SLC26A11-016	SLC26A11-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC26A11-001 ENSP00000355384 ENST00000361193	Q86WA9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008509 [anion transmembrane transporter activity] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	606 aa 65.3 kDa	No	>9
SLC26A11-002 ENSP00000440724 ENST00000546047	Q86WA9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008509 [anion transmembrane transporter activity] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	606 aa 65.3 kDa	No	>9
SLC26A11-003 ENSP00000459470 ENST00000572725	Q86WA9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008509 [anion transmembrane transporter activity] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	606 aa 65.3 kDa	No	>9
SLC26A11-005 ENSP00000403998 ENST00000411502	Q86WA9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005765 [lysosomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008509 [anion transmembrane transporter activity] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	606 aa 65.3 kDa	No	>9
SLC26A11-006 ENSP00000458521 ENST00000577155	I3L124 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	153 aa 16.3 kDa	No	5
SLC26A11-007 ENSP00000459735 ENST00000573809	I3L2J9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015116 [sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	64 aa 7.1 kDa	No	2
SLC26A11-009 ENSP00000459420 ENST00000576126	I3L266 [Direct mapping] Sodium-independent sulfate anion transporter Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015116 [sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	133 aa 14 kDa	No	0
SLC26A11-010 ENSP00000460535 ENST00000574967	I3L3K8 [Direct mapping] Sodium-independent sulfate anion transporter Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015116 [sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	77 aa 7.9 kDa	No	0
SLC26A11-013 ENSP00000458831 ENST00000571176	I3L1H1 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0015116 [sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	210 aa 22.5 kDa	No	7
SLC26A11-016 ENSP00000458234 ENST00000571215	I3L0N9 [Direct mapping] Sodium-independent sulfate anion transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0015116 [sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	197 aa 21.2 kDa	No	2
SLC26A11-017 ENSP00000459379 ENST00000575019	I3L250 [Direct mapping] Sodium-independent sulfate anion transporter Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.