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ADIPOQ

GENERAL INFORMATION

Gene name

 ADIPOQ

Gene description

 Adiponectin, C1Q and collagen domain containing

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adipose tissue)
GTEx:Group enriched (adipose tissue, breast)
FANTOM5:Tissue enhanced (adipose tissue, breast)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and plasma positivity in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.

Reliability score

 Uncertain based on 2 antibodies.
HPA051767 , CAB046467
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, breast)

GENE INFORMATION

Gene name

 ADIPOQ (HGNC Symbol)

Synonyms

 ACDC, ACRP30, adiponectin, AdipoQ, apM1, GBP28

Description

 Adiponectin, C1Q and collagen domain containing (HGNC Symbol)

Entrez gene summary

 This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Chromosome

 3

Cytoband

 q27.3

Chromosome location (bp)

 186842690 - 186858463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181092 (version 83.38)

Entrez gene

 9370

UniProt

 Q15848 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15848

Antibodypedia

 ADIPOQ antibodies

PROTEIN BROWSER
ADIPOQ-001
ADIPOQ-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADIPOQ-001
ENSP00000389814
ENST00000444204
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0009744 [response to sucrose]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0014823 [response to activity]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031667 [response to nutrient levels]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045471 [response to ethanol]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046888 [negative regulation of hormone secretion]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0051260 [protein homooligomerization]
GO:0051384 [response to glucocorticoid]
GO:0051899 [membrane depolarization]
GO:0060081 [membrane hyperpolarization]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070543 [response to linoleic acid]
GO:0070994 [detection of oxidative stress]
GO:0071320 [cellular response to cAMP]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:1900121 [negative regulation of receptor binding]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
 244 aa
26.4 kDa 		Yes 0
ADIPOQ-002
ENSP00000320709
ENST00000320741
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070994 [detection of oxidative stress]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:1900121 [negative regulation of receptor binding]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
 244 aa
26.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.