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MUC16

GENERAL INFORMATION

Gene name

 MUC16

Gene description

 Mucin 16, cell surface associated

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, fallopian tube)
GTEx:Tissue enhanced (salivary gland, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in mucinous cells of respiratory epithelia, salivary gland and cervix. Membranous expression in glandular cells of fallopian tube, uterus and ductal cells in salivary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB055172
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, cervix, uterine)

GENE INFORMATION

Gene name

 MUC16 (HGNC Symbol)

Synonyms

 CA125, FLJ14303

Description

 Mucin 16, cell surface associated (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 8848844 - 8981342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181143 (version 83.38)

Entrez gene

 94025

UniProt

neXtProt

Antibodypedia

 MUC16 antibodies

PROTEIN BROWSER
MUC16-001
MUC16-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUC16-001
ENSP00000381008
ENST00000397910
B5ME49 [Direct mapping]
Mucin-16
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005615 [extracellular space]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
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 14507 aa
1519.2 kDa 		No 1
MUC16-004
ENSP00000472781
ENST00000599436
M0R2S7 [Direct mapping]
Mucin-16
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 1330 aa
148.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.