Cell atlas - PENK - The Human Protein Atlas

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PENK

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PENK
Gene description	Proenkephalin
Protein class	Plasma proteins Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (BJ, ASC TERT1, THP-1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, ASC TERT1, THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PENK
Synonyms
Description	Proenkephalin (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	56436674 - 56446734
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181195 (version 83.38)
Entrez gene	5179
UniProt	P01210 (UniProt - Evidence at protein level)
neXtProt	NX_P01210
Antibodypedia	PENK antibodies

PROTEIN BROWSER

PENK-001	PENK-002	PENK-003	PENK-005	PENK-007	PENK-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PENK-001 ENSP00000400894 ENST00000451791	P01210 [Direct mapping] Proenkephalin-A Synenkephalin Met-enkephalin PENK(114-133) PENK(143-183) Met-enkephalin-Arg-Gly-Leu Leu-enkephalin PENK(237-258) Met-enkephalin-Arg-Phe A0A024R7V4 [Target identity:100%; Query identity:100%] Proenkephalin, isoform CRA_a Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0005184 [neuropeptide hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] Show all	267 aa 30.8 kDa	Yes	0
PENK-002 ENSP00000324248 ENST00000314922	P01210 [Direct mapping] Proenkephalin-A Synenkephalin Met-enkephalin PENK(114-133) PENK(143-183) Met-enkephalin-Arg-Gly-Leu Leu-enkephalin PENK(237-258) Met-enkephalin-Arg-Phe A0A024R7V4 [Target identity:100%; Query identity:100%] Proenkephalin, isoform CRA_a Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0001649 [osteoblast differentiation] GO:0001662 [behavioral fear response] GO:0001666 [response to hypoxia] GO:0001964 [startle response] GO:0002118 [aggressive behavior] GO:0005184 [neuropeptide hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] GO:0007568 [aging] GO:0007626 [locomotory behavior] GO:0009314 [response to radiation] GO:0009636 [response to toxic substance] GO:0014009 [glial cell proliferation] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032280 [symmetric synapse] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0034599 [cellular response to oxidative stress] GO:0035094 [response to nicotine] GO:0035641 [locomotory exploration behavior] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0043278 [response to morphine] GO:0043679 [axon terminus] GO:0045471 [response to ethanol] GO:0051592 [response to calcium ion] GO:0051867 [general adaptation syndrome, behavioral process] GO:0070852 [cell body fiber] GO:0071305 [cellular response to vitamin D] GO:0071320 [cellular response to cAMP] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071871 [response to epinephrine] GO:0098586 [cellular response to virus] GO:2000987 [positive regulation of behavioral fear response] Show all	267 aa 30.8 kDa	Yes	0
PENK-003 ENSP00000430592 ENST00000518770	E5RJ72 [Direct mapping] Proenkephalin-A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007218 [neuropeptide signaling pathway] Show all	92 aa 10.3 kDa	Yes	0
PENK-005 ENSP00000429326 ENST00000523051	E5RIP6 [Direct mapping] Proenkephalin-A Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007218 [neuropeptide signaling pathway] Show all	79 aa 8.8 kDa	Yes	0
PENK-007 ENSP00000430268 ENST00000517415	H0YBT5 [Direct mapping] Proenkephalin-A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007218 [neuropeptide signaling pathway] Show all	88 aa 10 kDa	Yes	0
PENK-010 ENSP00000428012 ENST00000518974	E5RFR1 [Direct mapping] Proenkephalin-A Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0005576 [extracellular region] GO:0007218 [neuropeptide signaling pathway] Show all	105 aa 11.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.