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POLR2A

CANCER ATLAS

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Protein class

 Enzymes, Predicted intracellular proteins, RNA polymerase related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021563
CAB012226
CAB016388
CAB022311

GENE INFORMATION

Gene name

 POLR2A (HGNC Symbol)

Synonyms

 POLR2, POLRA, RPB1

Description

 Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7484366 - 7514618

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181222 (version 83.38)

Entrez gene

 5430

UniProt

 P24928 (UniProt - Evidence at protein level)

neXtProt

 NX_P24928

Antibodypedia

 POLR2A antibodies

PROTEIN BROWSER
POLR2A-001
POLR2A-002
POLR2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2A-001
ENSP00000480158
ENST00000617998
A0A087WWE2 [Direct mapping]
DNA-directed RNA polymerase
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001047 [core promoter binding]
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005719 [nuclear euchromatin]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0014070 [response to organic cyclic compound]
GO:0071453 [cellular response to oxygen levels]
Show all
 1980 aa
218.2 kDa 		No 0
POLR2A-002
ENSP00000461879
ENST00000572844
P24928 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001055 [RNA polymerase II activity]
GO:0001172 [transcription, RNA-templated]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0003968 [RNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033120 [positive regulation of RNA splicing]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050434 [positive regulation of viral transcription]
Show all
 566 aa
63.6 kDa 		No 0
POLR2A-201
ENSP00000483957
ENST00000621442
A0A0C4DGZ0 [Direct mapping]
DNA-directed RNA polymerase
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
Show all
 1970 aa
217.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.