Cell atlas - FRAT2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FRAT2
Gene description	Frequently rearranged in advanced T-cell lymphomas 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049763
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the mitochondria.

Main location

Nucleus (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA049763	HEK 293	Nucleoplasm
HPA049763	HEK 293	Mitochondria	Intensity
HPA049763	PC-3	Nucleoplasm
HPA049763	U-2 OS	Nucleus

MOUSE CELLS

Main location

Mitochondria

Mouse gene

ENSMUSG00000047604 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049763	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	FRAT2
Synonyms
Description	Frequently rearranged in advanced T-cell lymphomas 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	97332497 - 97334709
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000181274 (version 83.38)
Entrez gene	23401
UniProt	O75474 (UniProt - Evidence at transcript level)
neXtProt	NX_O75474
Antibodypedia	FRAT2 antibodies

PROTEIN BROWSER

FRAT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRAT2-001 ENSP00000360058 ENST00000371019	O75474 [Direct mapping] GSK-3-binding protein FRAT2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	233 aa 24.1 kDa	No	0