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Most cancer cells displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Several gliomas and endometrial as well as a few renal cancers were negative.
Cancer cells displayed moderate to strong cytoplasmic staining. Additional nuclear and/or membranous positivity in a some cases. Cases of liver cancers were weakly stained.
ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]