Cell atlas - MAB21L2 - The Human Protein Atlas

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MAB21L2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MAB21L2
Gene description	Mab-21-like 2 (C. elegans)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA049324 , HPA059864
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA049324	BJ	Nucleoplasm
HPA049324	RH-30	Nucleus
HPA049324	RH-30	Cytosol
HPA059864	BJ	Nucleoplasm
HPA059864	RH-30	No staining
HPA059864	U-2 OS	No staining

GENE INFORMATION
Gene name	MAB21L2
Synonyms
Description	Mab-21-like 2 (C. elegans) (HGNC Symbol)
Entrez gene summary	This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.3
Chromosome location (bp)	150581922 - 150584693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181541 (version 83.38)
Entrez gene	10586
UniProt	Q9Y586 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y586
Antibodypedia	MAB21L2 antibodies

PROTEIN BROWSER

MAB21L2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAB21L2-001 ENSP00000324701 ENST00000317605	Q9Y586 [Direct mapping] Protein mab-21-like 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001654 [eye development] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007399 [nervous system development] GO:0008284 [positive regulation of cell proliferation] GO:0010172 [embryonic body morphogenesis] GO:0043010 [camera-type eye development] Show all	359 aa 40.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.