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Cancer tissues displayed moderate cytoplasmic positivity. Additional membranous staining was observed in colorectal cancers and a few renal cancers. Carcinoids, gliomas, lymphomas, urothelial, prostate and renal cancers were weakly stained or negative in a majority of cases.
GENE INFORMATION
Gene name
TMIE (HGNC Symbol)
Synonyms
DFNB6
Description
Transmembrane inner ear (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]
