Cell atlas - MRPS23 - The Human Protein Atlas

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MRPS23

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nuclear membrane

Human cell
	Mitochondria
	Nuclear membrane

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GENERAL INFORMATION
Gene name	MRPS23
Gene description	Mitochondrial ribosomal protein S23
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (supported), Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023453
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & mitochondria.

Main location

Nuclear membrane (supported), Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023453	A-431	Nuclear membrane	Spatial
	HPA023453	A-431	Mitochondria	Spatial
	HPA023453	U-2 OS	Nuclear membrane	Spatial
	HPA023453	U-2 OS	Mitochondria	Spatial
	HPA023453	U-251 MG	Nuclear membrane
	HPA023453	U-251 MG	Intermediate filaments

GENE INFORMATION
Gene name	MRPS23 (HGNC Symbol)
Synonyms	CGI-138, HSPC329, MRP-S23
Description	Mitochondrial ribosomal protein S23 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q22
Chromosome location (bp)	57834781 - 57850056
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181610 (version 83.38)
Entrez gene	51649
UniProt	Q9Y3D9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3D9
Antibodypedia	MRPS23 antibodies

PROTEIN BROWSER

MRPS23-001	MRPS23-003	MRPS23-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS23-001 ENSP00000320184 ENST00000313608	Q9Y3D9 [Direct mapping] 28S ribosomal protein S23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0045111 [intermediate filament cytoskeleton] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	190 aa 21.8 kDa	No	0
MRPS23-003 ENSP00000463481 ENST00000579380	J3QLC1 [Direct mapping] 28S ribosomal protein S23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.9 kDa	No	0
MRPS23-004 ENSP00000463677 ENST00000578444	J3QLR8 [Direct mapping] 28S ribosomal protein S23, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	152 aa 17.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.