Cell atlas - PLAG1 - The Human Protein Atlas

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PLAG1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PLAG1
Gene description	Pleiomorphic adenoma gene 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Cell line enhanced (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072290
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072290	HEK 293	Nuclear speckles
	HPA072290	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	PLAG1 (HGNC Symbol)
Synonyms	ZNF912
Description	Pleiomorphic adenoma gene 1 (HGNC Symbol)
Entrez gene summary	Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	56160904 - 56211324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181690 (version 83.38)
Entrez gene	5324
UniProt	Q6DJT9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6DJT9
Antibodypedia	PLAG1 antibodies

PROTEIN BROWSER

PLAG1-001	PLAG1-002	PLAG1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLAG1-001 ENSP00000416537 ENST00000429357	Q6DJT9 [Direct mapping] Zinc finger protein PLAG1 A0A024R7Z0 [Target identity:100%; Query identity:100%] Pleiomorphic adenoma gene 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	500 aa 55.9 kDa	No	0
PLAG1-002 ENSP00000404067 ENST00000423799	Q6DJT9 [Direct mapping] Zinc finger protein PLAG1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	418 aa 46.5 kDa	No	0
PLAG1-003 ENSP00000325546 ENST00000316981	Q6DJT9 [Direct mapping] Zinc finger protein PLAG1 A0A024R7Z0 [Target identity:100%; Query identity:100%] Pleiomorphic adenoma gene 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0022612 [gland morphogenesis] GO:0035264 [multicellular organism growth] GO:0035265 [organ growth] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0060252 [positive regulation of glial cell proliferation] GO:0060736 [prostate gland growth] Show all	500 aa 55.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.