Tissue expression of ADGRB1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADGRB1
Gene description	Adhesion G protein-coupled receptor B1
Protein class	Cancer-related genes G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, caudate, hypothalamus, hippocampus, cerebellum, pituitary gland)
FANTOM5:	Tissue enhanced (brain, caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, caudate, hypothalamus, hippocampus, cerebellum, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, caudate, hippocampus)

GENE INFORMATION
Gene name	ADGRB1 (HGNC Symbol)
Synonyms	BAI1
Description	Adhesion G protein-coupled receptor B1 (HGNC Symbol)
Entrez gene summary	Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142449430 - 142545009
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181790 (version 83.38)
Entrez gene	575
UniProt	O14514 (UniProt - Evidence at protein level)
neXtProt	NX_O14514
Antibodypedia	ADGRB1 antibodies

PROTEIN BROWSER

ADGRB1-001	ADGRB1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRB1-001 ENSP00000430945 ENST00000517894	O14514 [Direct mapping] Brain-specific angiogenesis inhibitor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007409 [axonogenesis] GO:0007422 [peripheral nervous system development] GO:0008285 [negative regulation of cell proliferation] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0051965 [positive regulation of synapse assembly] Show all	1584 aa 173.5 kDa	Yes	7
ADGRB1-201 ENSP00000313046 ENST00000323289	O14514 [Direct mapping] Brain-specific angiogenesis inhibitor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007409 [axonogenesis] GO:0007422 [peripheral nervous system development] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1584 aa 173.5 kDa	Yes	7