Cell atlas - SLC35C1 - The Human Protein Atlas

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SLC35C1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	SLC35C1
Gene description	Solute carrier family 35 (GDP-fucose transporter), member C1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA064001
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064001	A549	Golgi apparatus
	HPA064001	PC-3	Golgi apparatus
	HPA064001	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	SLC35C1 (HGNC Symbol)
Synonyms	FLJ11320, FUCT1
Description	Solute carrier family 35 (GDP-fucose transporter), member C1 (HGNC Symbol)
Entrez gene summary	This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	45804072 - 45813015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181830 (version 83.38)
Entrez gene	55343
UniProt	Q96A29 (UniProt - Evidence at protein level)
neXtProt	NX_Q96A29
Antibodypedia	SLC35C1 antibodies

PROTEIN BROWSER

SLC35C1-001	SLC35C1-002	SLC35C1-003	SLC35C1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35C1-001 ENSP00000313318 ENST00000314134	Q96A29 [Direct mapping] GDP-fucose transporter 1 B3KQH0 [Target identity:100%; Query identity:100%] Solute carrier family 35, member C1, isoform CRA_b; cDNA FLJ33926 fis, clone CTONG2017409, highly similar to GDP-fucose transporter 1; cDNA FLJ90448 fis, clone NT2RP3001271, highly similar to GDP-fucose transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002230 [positive regulation of defense response to virus by host] GO:0005794 [Golgi apparatus] GO:0008643 [carbohydrate transport] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030259 [lipid glycosylation] GO:0045746 [negative regulation of Notch signaling pathway] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	364 aa 39.8 kDa	No	>9
SLC35C1-002 ENSP00000412408 ENST00000442528	Q96A29 [Direct mapping] GDP-fucose transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002230 [positive regulation of defense response to virus by host] GO:0005794 [Golgi apparatus] GO:0008643 [carbohydrate transport] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	351 aa 38.2 kDa	No	>9
SLC35C1-003 ENSP00000432669 ENST00000530471	E9PPI4 [Direct mapping] GDP-fucose transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0098656 [anion transmembrane transport] Show all	165 aa 18 kDa	No	4
SLC35C1-004 ENSP00000432145 ENST00000526817	E9PS26 [Direct mapping] GDP-fucose transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015297 [antiporter activity] GO:0016021 [integral component of membrane] GO:0098656 [anion transmembrane transport] Show all	72 aa 7.9 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.