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RNF41

GENERAL INFORMATION

Gene name

 RNF41

Gene description

 Ring finger protein 41, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a several tissues, highest in testis, follicle cells and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016812
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNF41 (HGNC Symbol)

Synonyms

 NRDP1, SBBI03

Description

 Ring finger protein 41, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56202175 - 56221933

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181852 (version 83.38)

Entrez gene

 10193

UniProt

 Q9H4P4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4P4

Antibodypedia

 RNF41 antibodies

PROTEIN BROWSER
RNF41-001
RNF41-002
RNF41-006
RNF41-010
RNF41-011
RNF41-013
RNF41-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF41-001
ENSP00000342755
ENST00000345093
Q9H4P4 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
A0A024RB33 [Target identity:100%; Query identity:100%]
Ring finger protein 41, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005128 [erythropoietin receptor binding]
GO:0005135 [interleukin-3 receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010498 [proteasomal protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0017160 [Ral GTPase binding]
GO:0030336 [negative regulation of cell migration]
GO:0031386 [protein tag]
GO:0043408 [regulation of MAPK cascade]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045637 [regulation of myeloid cell differentiation]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051865 [protein autoubiquitination]
GO:0051896 [regulation of protein kinase B signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 317 aa
35.9 kDa 		No 0
RNF41-002
ENSP00000377581
ENST00000394013
Q9H4P4 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010498 [proteasomal protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0017160 [Ral GTPase binding]
GO:0030336 [negative regulation of cell migration]
GO:0031386 [protein tag]
GO:0043408 [regulation of MAPK cascade]
GO:0051865 [protein autoubiquitination]
GO:0051896 [regulation of protein kinase B signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 246 aa
28 kDa 		No 0
RNF41-006
ENSP00000447303
ENST00000552656
Q9H4P4 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
A0A024RB33 [Target identity:100%; Query identity:100%]
Ring finger protein 41, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010498 [proteasomal protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0017160 [Ral GTPase binding]
GO:0030336 [negative regulation of cell migration]
GO:0031386 [protein tag]
GO:0043408 [regulation of MAPK cascade]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
GO:0051896 [regulation of protein kinase B signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 317 aa
35.9 kDa 		No 0
RNF41-010
ENSP00000448187
ENST00000552244
F8VSB6 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0031386 [protein tag]
GO:0046872 [metal ion binding]
Show all
 201 aa
22.9 kDa 		No 0
RNF41-011
ENSP00000446595
ENST00000549038
F8VSP7 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0031386 [protein tag]
GO:0046872 [metal ion binding]
Show all
 190 aa
21.5 kDa 		No 0
RNF41-013
ENSP00000450164
ENST00000551711
F8VNZ6 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0031386 [protein tag]
Show all
 146 aa
16.8 kDa 		No 0
RNF41-201
ENSP00000484671
ENST00000615206
Q9H4P4 [Direct mapping]
E3 ubiquitin-protein ligase NRDP1
A0A024RB33 [Target identity:100%; Query identity:100%]
Ring finger protein 41, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010498 [proteasomal protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0017160 [Ral GTPase binding]
GO:0030336 [negative regulation of cell migration]
GO:0031386 [protein tag]
GO:0043408 [regulation of MAPK cascade]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
GO:0051896 [regulation of protein kinase B signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 317 aa
35.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.