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PRKAG1

GENERAL INFORMATION

Gene name

 PRKAG1

Gene description

 Protein kinase, AMP-activated, gamma 1 non-catalytic subunit

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRKAG1

Synonyms

Description

 Protein kinase, AMP-activated, gamma 1 non-catalytic subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49002274 - 49019197

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181929 (version 83.38)

Entrez gene

 5571

UniProt

 P54619 (UniProt - Evidence at protein level)

neXtProt

 NX_P54619

Antibodypedia

 PRKAG1 antibodies

PROTEIN BROWSER
«
PRKAG1-001
PRKAG1-002
PRKAG1-005
PRKAG1-006
PRKAG1-009
PRKAG1-010
PRKAG1-012
PRKAG1-014
PRKAG1-016
PRKAG1-017
PRKAG1-018
PRKAG1-019
PRKAG1-020
PRKAG1-021
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKAG1-001
ENSP00000447433
ENST00000548065
P54619 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
A0A024R125 [Target identity:100%; Query identity:100%]
Protein kinase, AMP-activated, gamma 1 non-catalytic subunit, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004679 [AMP-activated protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006110 [regulation of glycolytic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006633 [fatty acid biosynthetic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008286 [insulin receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016208 [AMP binding]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0043531 [ADP binding]
GO:0045860 [positive regulation of protein kinase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 331 aa
37.6 kDa 		No 0
PRKAG1-002
ENSP00000323867
ENST00000316299
P54619 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004679 [AMP-activated protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006110 [regulation of glycolytic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006633 [fatty acid biosynthetic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008286 [insulin receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016208 [AMP binding]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0043531 [ADP binding]
GO:0045860 [positive regulation of protein kinase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 340 aa
38.5 kDa 		No 0
PRKAG1-005
ENSP00000448972
ENST00000552212
P54619 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004679 [AMP-activated protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006110 [regulation of glycolytic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006633 [fatty acid biosynthetic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008286 [insulin receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016208 [AMP binding]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0043531 [ADP binding]
GO:0045860 [positive regulation of protein kinase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 299 aa
34.1 kDa 		No 0
PRKAG1-006
ENSP00000448873
ENST00000547306
F8VYY9 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 280 aa
31.9 kDa 		Yes 0
PRKAG1-009
ENSP00000448290
ENST00000547082
F8VSH3 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.9 kDa 		No 0
PRKAG1-010
ENSP00000448251
ENST00000552463
F8VSL2 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
14.4 kDa 		No 0
PRKAG1-012
ENSP00000448739
ENST00000548857
F8VRY2 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 82 aa
9.5 kDa 		No 0
PRKAG1-014
ENSP00000449104
ENST00000548605
F8VYZ8 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 28 aa
3.5 kDa 		No 0
PRKAG1-016
ENSP00000446987
ENST00000548362
H0YHF8 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 93 aa
10.7 kDa 		No 0
PRKAG1-017
ENSP00000449121
ENST00000551770
H0YIC9 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 251 aa
28.9 kDa 		No 0
PRKAG1-018
ENSP00000450273
ENST00000547125
F8VQQ1 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 43 aa
4.8 kDa 		No 0
PRKAG1-019
ENSP00000449637
ENST00000551121
F8VVA3 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 161 aa
18.7 kDa 		No 0
PRKAG1-020
ENSP00000450112
ENST00000548950
F8VPF5 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 145 aa
16.8 kDa 		No 0
PRKAG1-021
ENSP00000447671
ENST00000551696
F8VZX1 [Direct mapping]
5'-AMP-activated protein kinase subunit gamma-1
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 203 aa
23.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.