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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004448 [isocitrate dehydrogenase activity] GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006097 [glyoxylate cycle] GO:0006099 [tricarboxylic acid cycle] GO:0006102 [isocitrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0006102 [isocitrate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006097 [glyoxylate cycle] GO:0006099 [tricarboxylic acid cycle] GO:0006102 [isocitrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
