Expression of MRPL41 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L41

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024550	HPA027160

GENE INFORMATION
Gene name	MRPL41 (HGNC Symbol)
Synonyms	BMRP, MRP-L27, MRPL27, PIG3, RPML27
Description	Mitochondrial ribosomal protein L41 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137551199 - 137552555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182154 (version 83.38)
Entrez gene	64975
UniProt	Q8IXM3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXM3
Antibodypedia	MRPL41 antibodies

PROTEIN BROWSER

MRPL41-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL41-001 ENSP00000360498 ENST00000371443	Q8IXM3 [Direct mapping] 39S ribosomal protein L41, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007049 [cell cycle] GO:0030529 [ribonucleoprotein complex] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	137 aa 15.4 kDa	No	0