Expression of P2RY8 in cancer - Summary

CANCER ATLAS

Gene description

Purinergic receptor P2Y, G-protein coupled, 8

Protein class

Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003631

GENE INFORMATION
Gene name	P2RY8 (HGNC Symbol)
Synonyms	P2Y8
Description	Purinergic receptor P2Y, G-protein coupled, 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	1462572 - 1537107
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182162 (version 83.38)
Entrez gene	286530
UniProt	Q86VZ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VZ1
Antibodypedia	P2RY8 antibodies

PROTEIN BROWSER

P2RY8-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P2RY8-001 ENSP00000370697 ENST00000381297	Q86VZ1 [Direct mapping] P2Y purinoceptor 8 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	359 aa 40.6 kDa	No	7