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TSEN54

GENERAL INFORMATION

Gene name

 TSEN54

Gene description

 TSEN54 tRNA splicing endonuclease subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY

Data reliability
description

 Subcellular location is contradicted by limited external data.

Reliability score

 Uncertain based on 1 antibody.
HPA053097
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TSEN54 (HGNC Symbol)

Synonyms

 SEN54, SEN54L

Description

 TSEN54 tRNA splicing endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.[provided by RefSeq, Oct 2009]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75516060 - 75524739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182173 (version 83.38)

Entrez gene

 283989

UniProt

 Q7Z6J9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6J9

Antibodypedia

 TSEN54 antibodies

PROTEIN BROWSER
TSEN54-001
TSEN54-005
TSEN54-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSEN54-001
ENSP00000327487
ENST00000333213
Q7Z6J9 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 526 aa
58.8 kDa 		No 0
TSEN54-005
ENSP00000406559
ENST00000434205
E7EN92 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 72 aa
8.5 kDa 		No 0
TSEN54-012
ENSP00000438169
ENST00000545228
J9JIH8 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 259 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.