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SHMT2

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GENERAL INFORMATION

Gene name

 SHMT2

Gene description

 Serine hydroxymethyltransferase 2 (mitochondrial)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the microtubules.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (validated)

Additional location

 In addition localized to the Microtubules (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA020543 , HPA020549
SHOW MORE
All non detected compartments SHMT2 detected in Mitochondria and Microtubules

ASSAYS
AF22SH-SY5YU-138 MGU-251 MGU-87 MGA-431HaCaTSK-MEL-30WM-115HELHL-60HMC-1K-562NB-4THP-1U-937DaudiHDLM-2Karpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698A549SCLC-21HCACO-2CAPAN-2Hep G2AN3-CAEFO-21HeLaMCF7SiHaSK-BR-3T-47dHEK 293NTERA-2PC-3RPTEC TERT1RT4ASC TERT1LHCN-M2RH-30U-2 OSU-2197BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VHBF TERT88HUVEC TERT2TIMEBEWOhTCEpi05001,0001,5002,000
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
AF22SH-SY5YU-138 MGU-251 MGU-87 MGA-431HaCaTSK-MEL-30WM-115HELHL-60HMC-1K-562NB-4THP-1U-937DaudiHDLM-2Karpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698A549SCLC-21HCACO-2CAPAN-2Hep G2AN3-CAEFO-21HeLaMCF7SiHaSK-BR-3T-47dHEK 293NTERA-2PC-3RPTEC TERT1RT4ASC TERT1LHCN-M2RH-30U-2 OSU-2197BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VHBF TERT88HUVEC TERT2TIMEBEWOhTCEpi05001,0001,5002,000TPMBrainSkinMyeloidLymphoidLungAbdominalBreast, female reproductive systemRenal, urinary, male reproductive systemSarcomaFibroblastEndothelialMiscellaneous

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the microtubules.

Main location

 Mitochondria (validated)

Additional location

 Microtubules (validated)
HPA020543: A-431 1

HPA020543: A-431

 HPA020543: U-2 OS 2

HPA020543: U-2 OS

 HPA020543: U-251 MG 3

HPA020543: U-251 MG
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA020543 A-431 Microtubules
Mitochondria
HPA020543 U-2 OS Microtubules
Mitochondria
HPA020543 U-251 MG Microtubules
Mitochondria
HPA020549 A-431 Mitochondria
HPA020549 U-2 OS Microtubules
Mitochondria
HPA020549 U-251 MG Microtubules
Mitochondria

GENE INFORMATION

Gene name

 SHMT2 (HGNC Symbol)

Synonyms

 SHMT

Description

 Serine hydroxymethyltransferase 2 (mitochondrial) (HGNC Symbol)

Entrez gene summary

 This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57229327 - 57234935

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182199 (version 83.38)

Entrez gene

 6472

UniProt

 P34897 (UniProt - Evidence at protein level)

neXtProt

 NX_P34897

Antibodypedia

 SHMT2 antibodies

PROTEIN BROWSER
«
SHMT2-001
SHMT2-005
SHMT2-008
SHMT2-009
SHMT2-015
SHMT2-019
SHMT2-021
SHMT2-022
SHMT2-023
SHMT2-025
SHMT2-027
SHMT2-028
SHMT2-030
SHMT2-033
SHMT2-038
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHMT2-001
ENSP00000333667
ENST00000328923
P34897 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
V9HW06 [Target identity:100%; Query identity:100%]
Serine hydroxymethyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0006544 [glycine metabolic process]
GO:0006545 [glycine biosynthetic process]
GO:0006563 [L-serine metabolic process]
GO:0006564 [L-serine biosynthetic process]
GO:0006730 [one-carbon metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008732 [L-allo-threonine aldolase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0016597 [amino acid binding]
GO:0016740 [transferase activity]
GO:0019264 [glycine biosynthetic process from serine]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042645 [mitochondrial nucleoid]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
Show all
 504 aa
56 kDa 		No 0
SHMT2-005
ENSP00000406881
ENST00000414700
P34897 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
A0A024RB99 [Target identity:100%; Query identity:100%]
Serine hydroxymethyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042645 [mitochondrial nucleoid]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.5 kDa 		No 0
SHMT2-008
ENSP00000413770
ENST00000449049
P34897 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
A0A024RB99 [Target identity:100%; Query identity:100%]
Serine hydroxymethyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042645 [mitochondrial nucleoid]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.5 kDa 		No 0
SHMT2-009
ENSP00000452419
ENST00000553474
P34897 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
A0A024RB99 [Target identity:100%; Query identity:100%]
Serine hydroxymethyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042645 [mitochondrial nucleoid]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.5 kDa 		No 0
SHMT2-015
ENSP00000452315
ENST00000557487
P34897 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042645 [mitochondrial nucleoid]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0070062 [extracellular exosome]
Show all
 494 aa
54.9 kDa 		No 0
SHMT2-019
ENSP00000450930
ENST00000555634
G3V2Y4 [Direct mapping]
Serine hydroxymethyltransferase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
Show all
 234 aa
25.7 kDa 		No 0
SHMT2-021
ENSP00000450452
ENST00000557703
G3V241 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 142 aa
15.8 kDa 		No 0
SHMT2-022
ENSP00000452161
ENST00000553529
G3V3Y8 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 147 aa
16.3 kDa 		No 0
SHMT2-023
ENSP00000450893
ENST00000554310
G3V2W0 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 160 aa
17.7 kDa 		No 0
SHMT2-025
ENSP00000452045
ENST00000557427
G3V4X0 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 159 aa
17.6 kDa 		No 0
SHMT2-027
ENSP00000451968
ENST00000555773
G3V4T0 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 149 aa
16.4 kDa 		No 0
SHMT2-028
ENSP00000452404
ENST00000554975
G3V5L0 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 215 aa
24 kDa 		No 0
SHMT2-030
ENSP00000450490
ENST00000557529
H0YIZ0 [Direct mapping]
Serine hydroxymethyltransferase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0035999 [tetrahydrofolate interconversion]
Show all
 264 aa
28.7 kDa 		No 0
SHMT2-033
ENSP00000452035
ENST00000556689
G3V4W5 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 237 aa
26.3 kDa 		No 0
SHMT2-038
ENSP00000451495
ENST00000556737
G3V3Y8 [Direct mapping]
Serine hydroxymethyltransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016740 [transferase activity]
Show all
 147 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.