Expression of KCNA4 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated shaker related subfamily A, member 4

Protein class

FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA016422	CAB001977

GENE INFORMATION
Gene name	KCNA4 (HGNC Symbol)
Synonyms	HK1, HPCN2, KCNA4L, Kv1.4
Description	Potassium channel, voltage gated shaker related subfamily A, member 4 (HGNC Symbol)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
Chromosome	11
Cytoband	p14.1
Chromosome location (bp)	30009741 - 30017023
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182255 (version 83.38)
Entrez gene	3739
UniProt	P22459 (UniProt - Evidence at protein level)
neXtProt	NX_P22459
Antibodypedia	KCNA4 antibodies

PROTEIN BROWSER

KCNA4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNA4-001 ENSP00000328511 ENST00000328224	P22459 [Direct mapping] Potassium voltage-gated channel subfamily A member 4 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0030955 [potassium ion binding] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	653 aa 73.3 kDa	No	6