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GABRG3

GENERAL INFORMATION

Gene name

 GABRG3

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, gamma 3

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis, prostate)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA054010
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

 GABRG3

Synonyms

Description

 Gamma-aminobutyric acid (GABA) A receptor, gamma 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 15

Cytoband

 q12

Chromosome location (bp)

 26971282 - 27541991

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182256 (version 83.38)

Entrez gene

 2567

UniProt

 Q99928 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q99928

Antibodypedia

 GABRG3 antibodies

PROTEIN BROWSER
GABRG3-001
GABRG3-002
GABRG3-004
GABRG3-005
GABRG3-007
GABRG3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRG3-001
ENSP00000479113
ENST00000615808
Q99928 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005237 [inhibitory extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008503 [benzodiazepine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 467 aa
54.3 kDa 		Yes 4
GABRG3-002
ENSP00000452244
ENST00000555083
Q99928 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005237 [inhibitory extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008503 [benzodiazepine receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 253 aa
29.4 kDa 		Yes 0
GABRG3-004
ENSP00000390708
ENST00000451330
H7BZQ0 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004890 [GABA-A receptor activity]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 169 aa
19 kDa 		No 3
GABRG3-005
ENSP00000451862
ENST00000554696
H0YJP1 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 258 aa
30 kDa 		No 2
GABRG3-007
ENSP00000450976
ENST00000557596
H0YJ81 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 38 aa
4.3 kDa 		No 0
GABRG3-201
ENSP00000331912
ENST00000333743
A0A0A0MR73 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 288 aa
33.6 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.