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NLRP10

GENERAL INFORMATION

Gene name

 NLRP10

Gene description

 NLR family, pyrin domain containing 10

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skin)
GTEx:Tissue enriched (skin)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA039498 , HPA040101
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 NLRP10 (HGNC Symbol)

Synonyms

 CLR11.1, NALP10, NOD8, PAN5, Pynod

Description

 NLR family, pyrin domain containing 10 (HGNC Symbol)

Entrez gene summary

 Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 7959424 - 7965426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182261 (version 83.38)

Entrez gene

 338322

UniProt

 Q86W26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86W26

Antibodypedia

 NLRP10 antibodies

PROTEIN BROWSER
NLRP10-001
NLRP10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRP10-001
ENSP00000327763
ENST00000328600
Q86W26 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 10
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
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GO:0002250 [adaptive immune response]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0019897 [extrinsic component of plasma membrane]
GO:0035397 [helper T cell enhancement of adaptive immune response]
GO:0036336 [dendritic cell migration]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050832 [defense response to fungus]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000484 [positive regulation of interleukin-8 secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
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 655 aa
75 kDa 		No 0
NLRP10-002
ENSP00000436255
ENST00000526590
E9PPY0 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 10
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Predicted intracellular proteins
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 66 aa
7.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.