Cell atlas - KCNJ14 - The Human Protein Atlas

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KCNJ14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	KCNJ14
Gene description	Potassium channel, inwardly rectifying subfamily J, member 14
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071765
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071765	HaCaT	Nucleoli
	HPA071765	RT4	Nucleoli
	HPA071765	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	KCNJ14 (HGNC Symbol)
Synonyms	IRK4, Kir2.4
Description	Potassium channel, inwardly rectifying subfamily J, member 14 (HGNC Symbol)
Entrez gene summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48455509 - 48466980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182324 (version 83.38)
Entrez gene	3770
UniProt	Q9UNX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNX9
Antibodypedia	KCNJ14 antibodies

PROTEIN BROWSER

KCNJ14-001	KCNJ14-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ14-001 ENSP00000375756 ENST00000391884	Q9UNX9 [Direct mapping] ATP-sensitive inward rectifier potassium channel 14 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0043025 [neuronal cell body] Show all	436 aa 47.8 kDa	No	3
KCNJ14-002 ENSP00000341479 ENST00000342291	Q9UNX9 [Direct mapping] ATP-sensitive inward rectifier potassium channel 14 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	436 aa 47.8 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.