Tissue expression of C1S - Summary - The Human Protein Atlas

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C1S

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	C1S
Gene description	Complement component 1, s subcomponent
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Positivity in plasma.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA018852 , CAB016722
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	C1S
Synonyms
Description	Complement component 1, s subcomponent (HGNC Symbol)
Entrez gene summary	This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6988259 - 7071032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182326 (version 83.38)
Entrez gene	716
UniProt	P09871 (UniProt - Evidence at protein level)
neXtProt	NX_P09871
Antibodypedia	C1S antibodies

PROTEIN BROWSER

C1S-001	C1S-003	C1S-004	C1S-005	C1S-006	C1S-007	C1S-017	C1S-019	C1S-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1S-001 ENSP00000385035 ENST00000406697	P09871 [Direct mapping] Complement C1s subcomponent Complement C1s subcomponent heavy chain Complement C1s subcomponent light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	688 aa 76.7 kDa	Yes	0
C1S-003 ENSP00000328173 ENST00000328916	P09871 [Direct mapping] Complement C1s subcomponent Complement C1s subcomponent heavy chain Complement C1s subcomponent light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	688 aa 76.7 kDa	Yes	0
C1S-004 ENSP00000354057 ENST00000360817	P09871 [Direct mapping] Complement C1s subcomponent Complement C1s subcomponent heavy chain Complement C1s subcomponent light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	688 aa 76.7 kDa	Yes	0
C1S-005 ENSP00000399892 ENST00000423384	C9JY52 [Direct mapping] Complement C1s subcomponent Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.5 kDa	Yes	0
C1S-006 ENSP00000406643 ENST00000413211	C9IZP8 [Direct mapping] Complement C1s subcomponent Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.8 kDa	Yes	0
C1S-007 ENSP00000384464 ENST00000403949	B5MCV4 [Direct mapping] Complement C1s subcomponent Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	168 aa 19.3 kDa	Yes	0
C1S-017 ENSP00000384171 ENST00000402681	F8WCZ6 [Direct mapping] Complement C1s subcomponent Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] Show all	521 aa 57.5 kDa	No	0
C1S-019 ENSP00000442298 ENST00000542978	F5H7T4 [Direct mapping] Complement C1s subcomponent Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.4 kDa	No	0
C1S-201 ENSP00000484657 ENST00000617865	A0A087X232 [Direct mapping] Complement C1s subcomponent Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] Show all	682 aa 75.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.