Tissue expression of LIPF - Summary - The Human Protein Atlas

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LIPF

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LIPF
Gene description	Lipase, gastric
Protein class	Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (stomach)
GTEx:	Tissue enriched (stomach)
FANTOM5:	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in stomach.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045930
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (esophagus)

GENE INFORMATION
Gene name	LIPF (HGNC Symbol)
Synonyms	HGL, HLAL
Description	Lipase, gastric (HGNC Symbol)
Entrez gene summary	This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	88664441 - 88678814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182333 (version 83.38)
Entrez gene	8513
UniProt	P07098 (UniProt - Evidence at protein level)
neXtProt	NX_P07098
Antibodypedia	LIPF antibodies

PROTEIN BROWSER

LIPF-001	LIPF-002	LIPF-004	LIPF-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPF-001 ENSP00000238983 ENST00000238983	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	398 aa 45.2 kDa	Yes	0
LIPF-002 ENSP00000348101 ENST00000355843	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	375 aa 42.8 kDa	Yes	0
LIPF-004 ENSP00000377900 ENST00000394375	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0006108 [malate metabolic process] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016615 [malate dehydrogenase activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0055114 [oxidation-reduction process] Show all	408 aa 46.4 kDa	Yes	0
LIPF-006 ENSP00000477140 ENST00000608620	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	365 aa 41.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.