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CACNB4

CANCER ATLAS

Gene description

 Calcium channel, voltage-dependent, beta 4 subunit

Protein class

 Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015601

GENE INFORMATION

Gene name

 CACNB4 (HGNC Symbol)

Synonyms

 EJM4

Description

 Calcium channel, voltage-dependent, beta 4 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 2

Cytoband

 q23.3

Chromosome location (bp)

 151832776 - 152099079

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182389 (version 83.38)

Entrez gene

 785

UniProt

 O00305 (UniProt - Evidence at protein level)

neXtProt

 NX_O00305

Antibodypedia

 CACNB4 antibodies

PROTEIN BROWSER
CACNB4-001
CACNB4-002
CACNB4-003
CACNB4-004
CACNB4-005
CACNB4-006
CACNB4-009
CACNB4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNB4-001
ENSP00000438949
ENST00000539935
O00305 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0007628 [adult walking behavior]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014051 [gamma-aminobutyric acid secretion]
GO:0019227 [neuronal action potential propagation]
GO:0019901 [protein kinase binding]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042391 [regulation of membrane potential]
GO:0045202 [synapse]
GO:0046058 [cAMP metabolic process]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048541 [Peyer's patch development]
GO:0048747 [muscle fiber development]
GO:0050852 [T cell receptor signaling pathway]
GO:0050877 [neurological system process]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 520 aa
58.2 kDa 		No 0
CACNB4-002
ENSP00000380490
ENST00000397327
E7EN11 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0070588 [calcium ion transmembrane transport]
Show all
 473 aa
53.2 kDa 		No 0
CACNB4-003
ENSP00000443893
ENST00000534999
O00305 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0045202 [synapse]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 486 aa
54.7 kDa 		No 0
CACNB4-004
ENSP00000201943
ENST00000201943
O00305 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0045202 [synapse]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 458 aa
51.3 kDa 		No 0
CACNB4-005
ENSP00000410978
ENST00000427385
O00305 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0045202 [synapse]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:1901385 [regulation of voltage-gated calcium channel activity]
Show all
 502 aa
56.4 kDa 		No 0
CACNB4-006
ENSP00000390161
ENST00000439467
H0Y476 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0070588 [calcium ion transmembrane transport]
Show all
 515 aa
57.7 kDa 		No 0
CACNB4-009
ENSP00000399242
ENST00000434468
C9J224 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0070588 [calcium ion transmembrane transport]
Show all
 108 aa
12 kDa 		No 0
CACNB4-201
ENSP00000353425
ENST00000360283
E7DBM8 [Direct mapping]
Voltage-dependent L-type calcium channel subunit beta-4; Voltage-dependent calcium channel beta-4c subunit variant
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005891 [voltage-gated calcium channel complex]
GO:0007268 [synaptic transmission]
GO:0007528 [neuromuscular junction development]
GO:0070588 [calcium ion transmembrane transport]
Show all
 207 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.