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KCNK4

GENERAL INFORMATION

Gene name

 KCNK4

Gene description

 Potassium channel, two pore domain subfamily K, member 4

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (hippocampus, cerebral cortex, caudate, hypothalamus, cerebellum)
FANTOM5:Group enriched (caudate, hippocampus, brain, placenta, retina, cerebellum)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, cerebral cortex, caudate, hypothalamus, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus, brain, placenta, retina, cerebellum)

GENE INFORMATION

Gene name

 KCNK4 (HGNC Symbol)

Synonyms

 K2p4.1, TRAAK

Description

 Potassium channel, two pore domain subfamily K, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64291302 - 64300031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182450 (version 83.38)

Entrez gene

 50801

UniProt

 Q9NYG8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYG8

Antibodypedia

 KCNK4 antibodies

PROTEIN BROWSER
KCNK4-001
KCNK4-002
KCNK4-003
KCNK4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNK4-001
ENSP00000402797
ENST00000422670
Q9NYG8 [Direct mapping]
Potassium channel subfamily K member 4
A0A024R5C7 [Target identity:100%; Query identity:100%]
HCG1810791, isoform CRA_b
Show all
Voltage-gated ion channels
   Two-P Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0019233 [sensory perception of pain]
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0034705 [potassium channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071469 [cellular response to alkaline pH]
GO:0071502 [cellular response to temperature stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0097604 [temperature-gated cation channel activity]
GO:0098782 [mechanically-gated potassium channel activity]
Show all
 393 aa
42.7 kDa 		Yes 5
KCNK4-002
ENSP00000444948
ENST00000539216
Q9NYG8 [Direct mapping]
Potassium channel subfamily K member 4
A0A024R5C7 [Target identity:100%; Query identity:100%]
HCG1810791, isoform CRA_b
Show all
Voltage-gated ion channels
   Two-P Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0019233 [sensory perception of pain]
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0034705 [potassium channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071469 [cellular response to alkaline pH]
GO:0071502 [cellular response to temperature stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0097604 [temperature-gated cation channel activity]
GO:0098782 [mechanically-gated potassium channel activity]
Show all
 393 aa
42.7 kDa 		Yes 5
KCNK4-003
ENSP00000378033
ENST00000394525
Q9NYG8 [Direct mapping]
Potassium channel subfamily K member 4
A0A024R5C7 [Target identity:100%; Query identity:100%]
HCG1810791, isoform CRA_b
Show all
Voltage-gated ion channels
   Two-P Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0019233 [sensory perception of pain]
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0034705 [potassium channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071469 [cellular response to alkaline pH]
GO:0071502 [cellular response to temperature stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0097604 [temperature-gated cation channel activity]
GO:0098782 [mechanically-gated potassium channel activity]
Show all
 393 aa
42.7 kDa 		Yes 5
KCNK4-006
ENSP00000446454
ENST00000538767
F5GYE0 [Direct mapping]
Potassium channel subfamily K member 4
Show all
Predicted intracellular proteins
Show all
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 310 aa
32.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.