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FES

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GENERAL INFORMATION

Gene name

 FES

Gene description

 FES proto-oncogene, tyrosine kinase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to vesicles.

RNA cell category

 Cell line enhanced (HMC-1, THP-1, HEL)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Cytosol (approved)

Additional location

 In addition localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA001376
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, THP-1, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to vesicles.

Main location

 Nucleus (approved), Cytosol (approved)

Additional location

 Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001376 Hep G2 Nucleoplasm
Cytosol
HPA001376 U-2 OS Nucleus
Vesicles

GENE INFORMATION

Gene name

 FES (HGNC Symbol)

Synonyms

 FPS

Description

 FES proto-oncogene, tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 90883695 - 90895776

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182511 (version 83.38)

Entrez gene

 2242

UniProt

 P07332 (UniProt - Evidence at protein level)

neXtProt

 NX_P07332

Antibodypedia

 FES antibodies

PROTEIN BROWSER
FES-001
FES-005
FES-006
FES-007
FES-010
FES-011
FES-017
FES-018
FES-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FES-001
ENSP00000331504
ENST00000328850
P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
A0A024RC92 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0051297 [centrosome organization]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 822 aa
93.5 kDa 		No 0
FES-005
ENSP00000377837
ENST00000394300
P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 764 aa
86.7 kDa 		No 0
FES-006
ENSP00000377839
ENST00000394302
E7ENM8 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 681 aa
76.8 kDa 		No 0
FES-007
ENSP00000410477
ENST00000416779
C9J3W6 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 42 aa
4.8 kDa 		No 0
FES-010
ENSP00000392696
ENST00000452243
E7EMJ7 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 147 aa
16.9 kDa 		No 0
FES-011
ENSP00000395425
ENST00000443697
E9PGC7 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 115 aa
13 kDa 		No 0
FES-017
ENSP00000414629
ENST00000414248
P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 694 aa
78.6 kDa 		No 0
FES-018
ENSP00000400868
ENST00000444422
P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 752 aa
85.5 kDa 		No 0
FES-020
ENSP00000454089
ENST00000559355
H0YNN8 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 169 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.