Expression of ADI1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Acireductone dioxygenase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035403	HPA035404

GENE INFORMATION
Gene name	ADI1 (HGNC Symbol)
Synonyms	APL1, ARD, FLJ10913, HMFT1638, MTCBP-1, mtnD, SIPL
Description	Acireductone dioxygenase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	3497361 - 3519736
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182551 (version 83.38)
Entrez gene	55256
UniProt	Q9BV57 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV57
Antibodypedia	ADI1 antibodies

PROTEIN BROWSER

ADI1-001	ADI1-002	ADI1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADI1-001 ENSP00000333666 ENST00000327435	Q9BV57 [Direct mapping] 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006595 [polyamine metabolic process] GO:0010309 [acireductone dioxygenase [iron(II)-requiring] activity] GO:0016491 [oxidoreductase activity] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	179 aa 21.5 kDa	No	0
ADI1-002 ENSP00000371525 ENST00000382093	Q9BV57 [Direct mapping] 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase Show all	Enzymes ENZYME proteins Oxidoreductases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006595 [polyamine metabolic process] GO:0010309 [acireductone dioxygenase [iron(II)-requiring] activity] GO:0016491 [oxidoreductase activity] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	173 aa 20.3 kDa	No	0
ADI1-003 ENSP00000410178 ENST00000415131	H7C382 [Direct mapping] 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010309 [acireductone dioxygenase [iron(II)-requiring] activity] GO:0055114 [oxidation-reduction process] Show all	117 aa 12.2 kDa	Yes	0